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PubMed COVID-19 Clinical Care

331 - 340 of 44782 results found

On Inactivation of the Coronavirus Main Protease

Date
Thursday, February 29, 2024 - 4:00 AM
Description
A deeper understanding of the inactive conformations of the coronavirus main protease (MPro) could inform the design of allosteric drugs. Based on extensive molecular dynamics simulations, we built a Markov State Model to investigate structural

Steroidal lactones from Withania somnifera effectively target Beta, Gamma, Delta and Omicron variants of SARS-CoV-2 and reveal a decreased susceptibility to viral infection and perpetuation: a polypharmacology approach

Date
Thursday, February 29, 2024 - 4:00 AM
Description
Prevention from disease is presently the cornerstone of the fight against COVID-19. With the rapid emergence of novel SARS-CoV-2 variants, there is an urgent need for novel or repurposed agents to strengthen and fortify the immune system. Existing

Vaccination status and outcomes in critical COVID-19 patients

Date
Thursday, February 29, 2024 - 4:00 AM
Description
CONCLUSIONS: This study failed to show a significant improvement in outcomes in critically ill COVID-19 patients vaccinated against SARS-CoV-2. However, the CIs were wide and the mortality point estimates favored patients who received at least one

Characteristic functional connectome related to Post-COVID-19 syndrome

Date
Thursday, February 29, 2024 - 4:00 AM
Description
Post-COVID-19 syndrome is a serious complication following SARS-CoV-2 infection, characterized primarily by fatigue and cognitive complaints. Although first metabolic and structural imaging alterations in Post-COVID-19 syndrome have been identified