PubMed COVID-19 Clinical Care

Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warranted

Wednesday, January 17, 2024 - 4:00 AM

BACKGROUND: SARS-CoV-2-neutralizing antibodies (nABs) showed great promise in the early phases of the COVID-19 pandemic. The emergence of resistant strains, however, quickly rendered the majority of clinically approved nABs ineffective. This

Barriers and facilitators to the formation of professional identity among nursing students: A four-year longitudinal qualitative study

Wednesday, January 17, 2024 - 4:00 AM

CONCLUSIONS: The formation of nursing students' NPI is an ever-changing process, with various intrinsic and extrinsic influences during their four-year study. Nursing educators are suggested to prepare and develop students' professional comportment

Voice use of nurses working in the intensive care unit during the COVID-19 pandemic

Wednesday, January 17, 2024 - 4:00 AM

OBJECTIVE: This study aimed to investigate the voice use of nurses working in intensive care units (ICUs) and their perception of acoustic environments.

Correspondence regarding "Suicide trends in Germany during the COVID-19 pandemic and the war in Ukraine" by D. Radeloff et al

Wednesday, January 17, 2024 - 4:00 AM

No abstract

Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated pyroptosis of macrophages through mitochondrial damage by accelerating of the interaction between SCIMP and SYK pathway in acute lung injury

Wednesday, January 17, 2024 - 4:00 AM

Respiratory failure caused by severe acute lung injury (ALI) is the main cause of mortality in patients with COVID-19.This study aimed to investigate the effects and underlying biological mechanism of Apolipoprotein C3 (ApoC3) in ALI. To establish an

Interested to start a venture but worried about the future: Investigating the role of resilience in fear of career uncertainty and entrepreneurial intention

Wednesday, January 17, 2024 - 4:00 AM

Entrepreneurship is inherently characterised by immense uncertainty. Thereby, fear becomes an obvious experience and poses a significant threat to entrepreneurial intention (EI). This study aimed to extend this understanding by exploring how specific

Comparison of RT-ddPCR and RT-qPCR platforms for SARS-CoV-2 detection: Implications for future outbreaks of infectious diseases

Wednesday, January 17, 2024 - 4:00 AM

The increased frequency of human infectious disease outbreaks caused by RNA viruses worldwide in recent years calls for enhanced public health surveillance for better future preparedness. Wastewater-based epidemiology (WBE) is emerging as a valuable

Using Agent-Based Modeling to Examine Risk for COVID-19 Infection in Custodial Settings

Wednesday, January 17, 2024 - 4:00 AM

Research on pandemics in institutional settings often assumes that all human interactions within a jail pose similar viral transmission risks. We developed an agent-based model (ABM) called Simulation Applications for Forecasting Effective Responses

Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization

Wednesday, January 17, 2024 - 4:00 AM

In this paper we present the design, synthesis, and biological evaluation of a new series of peptidomimetics acting as potent anti-SARS-CoV-2 agents. Starting from our previously described Main Protease (M^(Pro)) and Papain Like Protease (PL^(Pro))

SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants

Wednesday, January 17, 2024 - 4:00 AM

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the rapidly evolving RNA virus behind the COVID-19 pandemic, has spawned numerous variants since its 2019 emergence. The multifunctional Nonstructural protein 14 (NSP14) enzyme, possessing